The Office of Research Compliance (ORC) assures the public that research at UH is performed responsibly and complies with federal, state, and university policies. Established in 2012, ORC provides support and services to the University of Hawai`i system of 10 campuses. The Institutional Animal Care & Use Committee (IACUC) is responsible for the oversight and evaluation of the animal care and use program and its components.
The Topaz protocol form requires that you first perform a search for duplication. It is required that you perform a search in at least two databases to determine the work is not unnecessarily duplicated. To complete this step, it is advised to search from at least two of the databases listed on the following page, Searching for Alternatives.
A database search is required when your protocol involves USDA-covered species at Pain Categories D and E. You must conduct a literature search in at least two databases to demonstrate that:
For more help with searching, see Searching for Alternatives.
The Animal Welfare Act (AWA) requires minimum standards of care and treatment for certain animals bred for commercial sale, used in research, transported commercially, or exhibited to the public. The AWA was signed into law in 1966. It is the only Federal law in the United States that regulates the treatment of animals in research, exhibition, transport, and by dealers. Other laws, policies, and guidelines may include additional species coverage or animal care and use specifications, but all refer to the Animal Welfare Act as the minimum acceptable standard. The Act is enforced by USDA, APHIS, and Animal Care.
--Adapted from the U.S. Department of Agriculture's Animal Welfare Act page.
The principles of the 3Rs (Replacement, Reduction, and Refinement) were developed as a framework for humane animal research. They have subsequently become embedded in national and international legislation regulating the use of animals in scientific procedures. The 3Rs are increasingly seen as a framework for conducting high-quality science in the academic and industrial sectors with more focus on developing alternative approaches that avoid the use of animals. There are a number of reasons for this, including the need for better models and tools that more closely reflect human biology and predict the efficacy and safety of new medicines.
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